![]() The process, known as adenylation, governed by the enzyme Poly-A polymerase forms the poly-A tail at the terminal end of the mRNA. Detection of polyadenylation or Poly A tail:.We will discuss the structure, function, and importance of Poly A tail. The present article is a bit in-depth and technical still I will try to explain it to you. The present piece of content concentrates on Poly A tailing of mRNA. ![]() MRNA without processing- known as pre-mRNA can’t form protein or abrupt protein product forms, henceforth mRNA processing such as 5’ capping and addition of Poly A tail on the 3’ end is required. The transcribed mRNA is known as “transcript”- having information only to encode a protein. The process is known as “RNA processing” is essential to protect the mRNA. Notably, not all three occur in a nucleus, the replication and transcription occur in a nucleus while translation occurs in the cell cytoplasm. RNA polymerase forms the functional mRNA through transcription and finally a protein product forms by translation of mRNA. Ī process of replication governed by the DNA polymerase forms copies of a gene or duplicate genes or DNA. Genes make protein via a three-step process, collectively known as central dogma processing, a combination of replication, transcription and translation. It converts the primary mRNA transcript to the mature mRNA and therefore it is important for translation to occur. Poly A tail plays a vital role in gene expression for both prokaryotes as well as eukaryotes. “Poly-A tail is a long chain of adenine nucleotides added to the 3’ end of the mRNA after the transcription and makes the mRNA stable and free from degradation.”
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